Río Salado (Spanish: Río SALADO), or Salado del Norte, is a river in northern Argentina, part of the La Plata Basin. It has a basin area of 124,199 km². The Río Salado originates on the slopes of the Andes in the province of Salta, where it is known as the Calchaquí River. After merging with the Santa María tributary, it takes on the name Guachipas. Upon leaving the mountainous region, it joins with the Arias tributary, becoming the Pasaje or Juramento River, and forms the Cabra Corral Reservoir.
From the city of Santiago del Estero, the river is called Salado or Cachimayo. In the province of Santiago del Estero, Río Salado feeds an extensive network of irrigation canals. Near the borders of Santa Fe province, the river merges with the Calchaquí del Sur, and later receives waters from the San Antonio and Cululú rivers. At the confluence of the Río Salado and Saladillo lies the city of Santa Fe. Beyond this point, the Río Salado splits into two branches: one flows into the Paraná River, while the other, called Río Coronda, continues for another 150 km before also merging with the Paraná.
The Río Salado has a total length of 2,355 km.